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Mouse anti-Plasma Cell Marker, Clone: SPM310, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP23435905ML

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For Research Use Only

Catalog No. NBP23435905


Description & Specifications


Antigen Plasma Cell Marker
Applications Immunohistochemistry (Paraffin)
Clone SPM310
Concentration 0.2mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation PBS with 0.05% BSA.
Host Species Mouse
Immunogen Pancreatic cancer-related mucin
Isotype IgG2a
Purification Method Purified
Quantity 0.5mL
Regulatory Status RUO
Storage Requirements Store at 4°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Test Specificity It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues. Does not react with Rat.
Reconstitution Protein A purified