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Mouse anti-Plasma Cell Marker, Clone: SPM310, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23440701MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23440701

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Description & Specifications

Specifications

Formulation 10mM PBS. Does not contain BSA. Azide Free.
Applications Immunohistochemistry (Paraffin)
Cross Reactivity Human
Antigen Plasma Cell Marker
Format Purified
Host Species Mouse
Isotype IgG2a
Storage Requirements Store at -20 to -80°C. Avoid freeze-thaw cycles.
Monoclonal or Polyclonal Monoclonal
Test Specificity It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues. Does not react with Rat.
Reconstitution Protein A purified
Concentration 1mg/mL
Conjugate Unlabeled
Immunogen Pancreatic cancer-related mucin
Purification Method Purified
Quantity 0.1mg
Regulatory Status RUO
Primary or Secondary Primary
Clone SPM310