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Mouse anti-Plasma Cell Marker, Clone: SPM310, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23440701MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23440701

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Description & Specifications

Specifications

Applications Immunohistochemistry (Paraffin)
Cross Reactivity Human
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Antigen Plasma Cell Marker
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Concentration 1mg/mL
Format Purified
Storage Requirements Store at -20 to -80°C. Avoid freeze-thaw cycles.
Host Species Mouse
Isotype IgG2a
Test Specificity It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues. Does not react with Rat.
Reconstitution Protein A purified
Purification Method Purified
Clone SPM310
Immunogen Pancreatic cancer-related mucin
Regulatory Status RUO
Primary or Secondary Primary
Quantity 0.1mg