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Mouse anti-Plasma Cell Marker, Clone: SPM310, Azide Free, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP23440701MG

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Catalog No. NBP23440701


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

Plasma Cell Marker
SPM310
Unlabeled
10mM PBS. Does not contain BSA. Azide Free.
Pancreatic cancer-related mucin
Purified
RUO
Primary
It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues. Does not react with Rat.
Human
Immunohistochemistry (Paraffin)
1mg/mL
Purified
Murine
IgG2a
0.1mg
Store at -20 to -80°C. Avoid freeze-thaw cycles.
Monoclonal
Protein A purified