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Mouse anti-HLA-DR, Clone: SPM289, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23475602MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23475602

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Description & Specifications

Specifications

Antigen HLA-DR
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone SPM289
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Gene Accession No. P01903
Host Species Mouse
Immunogen Activated human peripheral blood mononuclear cells
Isotype IgG2b, κ
Purification Method Purified
Quantity 0.2mg
Regulatory Status RUO
Storage Requirements Store at -20 to -80°C. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 3122
Test Specificity This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Reconstitution Protein A purified