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Mouse anti-HLA-DR, Clone: LN-3, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23446401ML

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 Disclaimers

For Research Use Only

Catalog No. NBP23446401

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Description & Specifications

Specifications

Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Format Purified
Host Species Mouse
Isotype IgG2b, κ
Purification Method Purified
Quantity 0.1mL
Storage Requirements Store at 4°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Test Specificity This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Does not react with Mouse.
Reconstitution Protein A purified
Cross Reactivity Human
Cross Reactivity Primate
Antigen HLA-DR
Formulation PBS with 0.05% BSA.
Gene Accession No. P01903
Immunogen Activated human peripheral blood mononuclear cells
Regulatory Status RUO
Gene ID (Entrez) 3122
Clone LN-3
Concentration 0.2mg/mL
Conjugate Unlabeled