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Mouse anti-HLA-DR, Clone: LN-3, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23446405ML

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 Disclaimers

For Research Use Only

Catalog No. NBP23446405

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Description & Specifications

Specifications

Format Purified
Quantity 0.5mL
Conjugate Unlabeled
Antigen HLA-DR
Gene Accession No. P01903
Host Species Mouse
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Activated human peripheral blood mononuclear cells
Purification Method Purified
Regulatory Status RUO
Storage Requirements Store at 4°C. Do not freeze.
Primary or Secondary Primary
Gene ID (Entrez) 3122
Test Specificity This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Does not react with Mouse.
Reconstitution Protein A purified
Concentration 0.2mg/mL
Cross Reactivity Human
Cross Reactivity Primate
Formulation PBS with 0.05% BSA.
Isotype IgG2b, κ
Monoclonal or Polyclonal Monoclonal
Clone LN-3