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Mouse anti-HLA-DR, Clone: LN-3, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23467601MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23467601

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Description & Specifications

Specifications

Immunogen Activated human peripheral blood mononuclear cells
Format Purified
Regulatory Status RUO
Antigen HLA-DR
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Gene ID (Entrez) 3122
Gene Accession No. P01903
Conjugate Unlabeled
Storage Requirements Store at -20 to -80°C. Avoid freeze-thaw cycles.
Host Species Mouse
Cross Reactivity Human
Cross Reactivity Primate
Quantity 0.1mg
Concentration 1mg/mL
Isotype IgG2b, κ
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Purification Method Purified
Test Specificity This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Does not react with Mouse.
Clone LN-3
Reconstitution Protein A purified