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Mouse anti-Cytokeratin 19, Clone: A53-B/A2.26, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21518601MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21518601

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Description & Specifications

Specifications

Antigen Cytokeratin 19
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone A53-B/A2.26
Concentration 0.2mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation PBS with 0.05% BSA. Protein G purified.
Gene Accession No. P08727
Host Species Mouse
Immunogen Human breast cancer MCF-7 cells were used as the immunogen for the Keratin-19 antibody.
Isotype IgG2a, κ
Purification Method Purified
Quantity 0.1mg
Regulatory Status RUO
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 3880
Test Specificity This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer. The A53-B antibody strongly binds to human Keratin-19 and weakly binds to mouse, rat and guinea pig Keratin-19.