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Mouse anti-Cyclin D1, Clone: DCS-6, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP21518902MG

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Catalog No. NBP21518902


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

Cyclin D1
DCS-6
Unlabeled
PBS with 0.05% BSA. Protein G purified.
Murine
IgG2a, κ
0.2mg
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
ELISA,Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
0.2mg/mL
Purified
P24385
Human recombinant full length Cyclin D1 protein was used as immunogen to generate this antibody.
Purified
RUO
Primary
595
Human,Murine,Primate,Rat