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Mouse anti-Cyclin D1, Clone: DCS-6, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21518902MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21518902

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Description & Specifications

Specifications

Gene Accession No. P24385
Isotype IgG2a, κ
Regulatory Status RUO
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Primate
Cross Reactivity Rat
Antigen Cyclin D1
Formulation PBS with 0.05% BSA. Protein G purified.
Host Species Mouse
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Human recombinant full length Cyclin D1 protein was used as immunogen to generate this antibody.
Purification Method Purified
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 595
Clone DCS-6
Format Purified
Quantity 0.2mg
Primary or Secondary Primary
Test Specificity Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Concentration 0.2mg/mL