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Mouse anti-Cyclin D1, Clone: DCS-6, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21518901MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21518901

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Description & Specifications

Specifications

Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Primate
Cross Reactivity Rat
Host Species Mouse
Formulation PBS with 0.05% BSA. Protein G purified.
Antigen Cyclin D1
Conjugate Unlabeled
Isotype IgG2a, κ
Test Specificity Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Immunogen Human recombinant full length Cyclin D1 protein was used as immunogen to generate this antibody.
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Regulatory Status RUO
Purification Method Purified
Gene ID (Entrez) 595
Monoclonal or Polyclonal Monoclonal
Quantity 0.1mg
Concentration 0.2mg/mL
Gene Accession No. P24385
Clone DCS-6
Format Purified