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Mouse anti-Cyclin D1, Clone: DCS-6, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21518901MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21518901

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Description & Specifications

Specifications

Antigen Cyclin D1
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone DCS-6
Concentration 0.2mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Primate
Cross Reactivity Rat
Format Purified
Formulation PBS with 0.05% BSA. Protein G purified.
Gene Accession No. P24385
Host Species Mouse
Immunogen Human recombinant full length Cyclin D1 protein was used as immunogen to generate this antibody.
Isotype IgG2a, κ
Purification Method Purified
Quantity 0.1mg
Regulatory Status RUO
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 595
Test Specificity Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.