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Mouse anti-CD8 alpha, Clone: C8/468, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP22942601ML

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 Disclaimers

For Research Use Only

Catalog No. NBP22942601

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Description & Specifications

Specifications

Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Formulation Culture Medium. Bioreactor concentrate.
Gene Accession No. P01732
Host Species Mouse
Quantity 0.1mL
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Cross Reactivity Human
Antigen CD8 alpha
Format Concentrated
Immunogen A recombinant C-terminus protein fragment specific to CD8 was used as the immunogen for the C8/468 antibody.
Isotype IgG1, κ
Purification Method Concentrated
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 925
Test Specificity CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Clone C8/468
Conjugate Unlabeled