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Mouse anti-CD63, Clone: MX-49.129.5, Azide Free, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP23468902MG

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For Research Use Only

Catalog No. NBP23468902

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Description & Specifications


Regulatory Status RUO
Test Specificity This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Host Species Mouse
Storage Requirements Store at -20 to -80°C. Avoid freeze-thaw cycles.
Cross Reactivity Human
Cross Reactivity Mouse
Concentration 1mg/mL
Immunogen Full length CD63 of human origin
Gene ID (Entrez) 967
Applications ELISA
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Reconstitution Protein A purified
Purification Method Purified
Primary or Secondary Primary
Conjugate Unlabeled
Quantity 0.2mg
Monoclonal or Polyclonal Monoclonal
Isotype IgG1, κ
Antigen CD63
Clone MX-49.129.5
Gene Accession No. P08962
Format Purified