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Mouse anti-CD63, Clone: MX-49.129.5, Azide Free, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP23468902MG

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Catalog No. NBP23468902


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

CD63
MX-49.129.5
Unlabeled
10mM PBS. Does not contain BSA. Azide Free.
Murine
IgG1, κ
0.2mg
Store at -20 to -80°C. Avoid freeze-thaw cycles.
Monoclonal
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Human,Murine
ELISA,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
1mg/mL
Purified
P08962
Full length CD63 of human origin
Purified
RUO
Primary
967
Protein A purified