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Mouse anti-CA19-9, Clone: 121SLE, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21518205ML

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For Research Use Only

Catalog No. NBP21518205

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Description & Specifications

Specifications

Cross Reactivity Human
Primary or Secondary Primary
Formulation Culture Medium. Bioreactor concentrate.
Gene ID (Entrez) 3362
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Test Specificity CA19-9, a carbohydrate epitope expressed on a high MW (>400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This MAb is superb for staining of formalin-fixed, paraffin-embedded tissues.
Quantity 0.5mL
Clone 121SLE
Format Concentrated
Regulatory Status RUO
Antigen CA19-9
Host Species Mouse
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Immunogen Precipitin lines obtained after immunodiffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le) were used as immunogen for this CA19-9 antibody.
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Isotype IgM, κ
Gene Accession No. P50406
Purification Method Concentrated