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Mouse anti-Bcl-2, Clone: 100/D5, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21520001MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21520001

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Description & Specifications

Specifications

Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Quantity 0.1mg
Gene ID (Entrez) 596
Antigen Bcl-2
Host Species Mouse
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Formulation PBS with 0.05% BSA. Protein G purified.
Primary or Secondary Primary
Cross Reactivity Human
Test Specificity This antibody recognizes a protein of 25-26kDa, identified as the bcl-2alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative. Does not react with Mouse or Rat.
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Gene Accession No. P10415
Regulatory Status RUO
Format Purified
Isotype IgG1, κ
Clone 100/D5
Concentration 0.2mg/mL
Immunogen 1990).
Purification Method Purified
Reconstitution Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes.