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Mouse anti-Bcl-2, Clone: 100/D5, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP21520002MG

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Catalog No. NBP21520002


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

Bcl-2
100/D5
Unlabeled
PBS with 0.05% BSA. Protein G purified.
Murine
IgG1, κ
0.2mg
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative. Does not react with Mouse or Rat.
Human
ELISA,Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
0.2mg/mL
Purified
P10415
1990).
Purified
RUO
Primary
596
Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes.