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Thermo Scientific™ Lab Vision™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

$527.24 - $1,719.57

Specifications

Antigen MMP-14/MT1-MMP Ab-2
Concentration 1mg/mL
Applications Western Blot
Classification Polyclonal
Conjugate Unlabeled
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Concentration Format Quantity Price Quantity  
Catalog Number Mfr. No. Concentration Format Quantity Price Quantity  
RB1545P Thermo Scientific™ Lab Vision™
RB1545P
1mg/mL Purified with BSA and azide 1mL Each for $1,594.04
RB1545P0 Thermo Scientific™ Lab Vision™
RB1545P0
1mg/mL Purified with BSA and azide 100μL Each for $527.24
RB1545P1 Thermo Scientific™ Lab Vision™
RB1545P1
1mg/mL Purified with BSA and azide 500μL Each for $1,102.31
RB1545P1ABX Thermo Scientific™ Lab Vision™
RB1545P1ABX
1mg/mL Purified without BSA and azide 500μL Each for $1,216.84
RB1545PABX Thermo Scientific™ Lab Vision™
RB1545PABX
1mg/mL Purified without BSA and azide 1mL Each for $1,719.57
Specifications

Description

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: Hemopexin-like domain

Immunogen: A synthetic peptide from the hemopexin-like domain of human MMP-14/MT1-MMP

Molecular Weight: ∽66kDa (latent) and ∽54kDa (active)

Positive Control: Recombinant MMP-14 protein; Conditioned, serum-free medium from (TPA-treated ) HFL-1 cells

Cellular Localization: Membrane and cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

MMP-14/MT1-MMP Ab-2
Western Blot
Unlabeled
RUO
Primary
1mg/mL
Polyclonal
Rabbit
Proteases And Inhibitors
IgG