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Thermo Scientific™ Lab Vision™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

$490.33 - $1,599.18

Specifications

Antigen MMP-14/MT1-MMP Ab-2
Concentration 1mg/mL
Applications Western Blotting
Classification Polyclonal
Conjugate Unlabeled
View More Specs
Products
Catalog Number Mfr. No. Concentration Format Quantity Price Quantity    

RB1545P

 
thermo scientific™ lab vision™
RB-1545-P
1mg/mL Purified with BSA and azide 1mL Each for $1,482.43

RB1545P0

 
thermo scientific™ lab vision™
RB-1545-P0
1mg/mL Purified with BSA and azide 100µL Each for $490.33

RB1545P1

 
thermo scientific™ lab vision™
RB-1545-P1
1mg/mL Purified with BSA and azide 500µL Each for $1,025.22

RB1545P1ABX

 
thermo scientific™ lab vision™
RB1545P1ABX
1mg/mL Purified without BSA and azide 500µL Each for $1,131.78

RB1545PABX

 
thermo scientific™ lab vision™
RB1545PABX
1mg/mL Purified without BSA and azide 1mL Each for $1,599.18
Description & Specifications

Specifications

Antigen MMP-14/MT1-MMP Ab-2
Concentration 1mg/mL
Applications Western Blotting
Classification Polyclonal
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Human
Cross Reactivity Mouse
Host Species Rabbit
Regulatory Status RUO
Research Discipline Proteases And Inhibitors
Type Primary
Isotype IgG

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: Hemopexin-like domain

Immunogen: A synthetic peptide from the hemopexin-like domain of human MMP-14/MT1-MMP

Molecular Weight: ∽66kDa (latent) and ∽54kDa (active)

Positive Control: Recombinant MMP-14 protein; Conditioned, serum-free medium from (TPA-treated ) HFL-1 cells

Cellular Localization: Membrane and cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO