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Thermo Scientific™ Lab Vision™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ RB1545PABX

 View more versions of this product

Catalog No. RB1545PABX


 

Specifications

Description

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: Hemopexin-like domain

Immunogen: A synthetic peptide from the hemopexin-like domain of human MMP-14/MT1-MMP

Molecular Weight: ∽66kDa (latent) and ∽54kDa (active)

Positive Control: Recombinant MMP-14 protein; Conditioned, serum-free medium from (TPA-treated ) HFL-1 cells

Cellular Localization: Membrane and cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

MMP-14/MT1-MMP Ab-2
Polyclonal
Unlabeled
Purified without BSA and azide
A synthetic peptide from the hemopexin-like domain of human MMP-14 / MT1-MMP
Recombinant MMP14 protein, Conditioned, serum free
RUO
Primary
Human,Murine
Western Blot
1mg/mL
Human,Mouse
Rabbit
IgG
1mL
Proteases And Inhibitors
Polyclonal