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Thermo Scientific™ Lab Vision™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody


Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB1545P1ABX

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Catalog No. RB1545P1ABX

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Description & Specifications

Specifications

Antigen MMP-14/MT1-MMP Ab-2
Applications Western Blotting
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Purified without BSA and azide
Host Species Rabbit
Immunogen A synthetic peptide from the hemopexin-like domain of human MMP-14 / MT1-MMP
Isotype IgG
Purification Method Recombinant MMP14 protein, Conditioned, serum free
Quantity 500µL
Regulatory Status RUO
Research Discipline Proteases And Inhibitors
Type Primary

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: Hemopexin-like domain

Immunogen: A synthetic peptide from the hemopexin-like domain of human MMP-14/MT1-MMP

Molecular Weight: ∽66kDa (latent) and ∽54kDa (active)

Positive Control: Recombinant MMP-14 protein; Conditioned, serum-free medium from (TPA-treated ) HFL-1 cells

Cellular Localization: Membrane and cytoplasmic

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO