Thermo Scientific™ Lab Vision™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody
Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ RB1545P1ABX
Ensure accurate, reproducible results in experiments with the Thermo Scientific™ MMP-14/MT1-MMP Ab-2, Rabbit Polyclonal Antibody.MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form.
Host Species: Rabbit
Species Reactivity: Human and Mouse. Others not known.
Epitope: Hemopexin-like domain
Immunogen: A synthetic peptide from the hemopexin-like domain of human MMP-14/MT1-MMP
Molecular Weight: ∽66kDa (latent) and ∽54kDa (active)
Positive Control: Recombinant MMP-14 protein; Conditioned, serum-free medium from (TPA-treated ) HFL-1 cells
Cellular Localization: Membrane and cytoplasmic
- Immunohistochemistry (Not suitable)
- Western Blotting
USA: RUO; Int'l: RUO
|Proteases And Inhibitors|
|Purified without BSA and azide|
|A synthetic peptide from the hemopexin-like domain of human MMP-14 / MT1-MMP|
|Recombinant MMP14 protein, Conditioned, serum free|