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Thermo Scientific™ Lab Vision™ MMP-1 (Collagenase-1) Ab-6, Rabbit Polyclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry and western blotting experiments with the Thermo Scientific™ MMP-1 (Collagenase-1) Ab-6, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB1536PABX

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Catalog No. RB1536PABX

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Description & Specifications

Specifications

Antigen MMP-1 (Collagenase-1) Ab-6
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide from the middle region of the human MMP-1
Isotype IgG
Quantity 1mL
Regulatory Status RUO
Research Discipline Proteases And Inhibitors
Type Primary

Ensure accurate, reproducible results in immunohistochemistry and western blotting experiments with the Thermo Scientific™ MMP-1 (Collagenase-1) Ab-6, Rabbit Polyclonal Antibody.

Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) are implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1), 72kDa gelatinase A/type IV collagenase (MMP-2), and 92kDa gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human. Does not react with cow. Others not known.

Epitope: Middle region of MMP-1

Immunogen: A synthetic peptide from the middle region of the human MMP-1

Molecular Weight: 52kDa (unglycosylated) and 57kDa (glycosylated) species of proform of MMP-1 plus 42kDa (unglycosylated) and 47kDa (glycosylated) active form of MMP-1

Positive Control: Conditioned, serum-free medium from (TPA-treated) HFL-1 cells; Placenta; Bladder, breast, ovarian, colon CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO