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Microphthalmia (Transcription Factor) (MiTF) Ab-2 Mouse Monoclonal Antibody, Epredia™
Ensure accurate, reproducible results in immunohistochemistry experiments with the Epredia™ Microphthalmia (Transcription Factor) (MiTF) Ab-2, Mouse Monoclonal Antibody.
Supplier: Thermo Fisher Scientific MS772P
Description
Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.Host Species: Mouse
Clone: D5
Isotype: IgG1/κ
Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.
Epitope: N-terminal
Immunogen: N-terminal fragment of human Mi protein
Molecular Weight: 52-56kDa doublet
Positive Control: 501 Mel cells, Melanoma
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not verified)
- Gel Supershift
Note:
USA: RUO; Int'l: RUO
Specifications
| Microphthalmia (Transcription Factor) (MiTF) Ab-2 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 1 mL | |
| Transcription Regulation | |
| Canine, Human | |
| IgG2a κ |
| Immunohistochemistry (Paraffin) | |
| D5 | |
| Unconjugated | |
| N-terminal fragment of human Mi protein | |
| RUO | |
| Primary | |
| Concentrated |