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Thermo Scientific™ Lab Vision™ Microphthalmia (Transcription Factor) (MiTF) Ab-2, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Microphthalmia (Transcription Factor) (MiTF) Ab-2, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS772P1ABX

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Catalog No. MS772P1ABX


 

Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Microphthalmia (Transcription Factor) (MiTF) Ab-2, Mouse Monoclonal Antibody.

Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.

Host Species: Mouse

Clone: D5

Isotype: IgG1/κ

Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.

Epitope: N-terminal

Immunogen: N-terminal fragment of human Mi protein

Molecular Weight: 52-56kDa doublet

Positive Control: 501 Mel cells, Melanoma

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Gel Supershift

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Microphthalmia (Transcription Factor) (MiTF) Ab-2
Monoclonal
1mg/mL
Canine,Human
Ab Without BSA/Azide (Frozen)
N-terminal fragment of human Mi protein
100μL
Transcription Regulation
Monoclonal
Immunohistochemistry (Paraffin)
D5
Unlabeled
Concentrated
Murine
IgG2a kappa
RUO
Primary
Canine,Human