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Thermo Scientific Microphthalmia (Transcription Factor) (MiTF) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Microphthalmia (Transcription Factor) (MiTF) Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific MS771P1ABX

 View more versions of this product

Catalog No. MS771P1ABX


 

Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Microphthalmia (Transcription Factor) (MiTF) Ab-1, Mouse Monoclonal Antibody.

Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.

Host Species: Mouse

Clone: C5

Isotype: IgG1/κ

Species Reactivity: Human, Horse, Dog, Mouse and Rat. Others not known.

Epitope: N-terminal

Immunogen: N-terminal fragment of human Mi protein

Molecular Weight: 52-56kDa doublet

Positive Control: 501 Mel cells, colo32 cells

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Gel Supershift

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Microphthalmia (Transcription Factor) (MiTF) Ab-1
Monoclonal
1mg/mL
Purified
N-terminal fragment of human Mi protein
100μL
Transcription Regulation
Monoclonal
Immunohistochemistry (Paraffin),Western Blotting
C5
Canine,Equine,Human,Mouse,Rat
Murine
IgG1/k
RUO
Primary
Canine,Equine,Human,Murine,Rat