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MICA/B Mouse anti-Human, Clone: 6D4, eBioscience™

Mouse Monoclonal Antibody

$100.05 - $158.05

Specifications

Antigen MICA/B
Clone 6D4
Host Species Murine
Gene Alias MICA/MICB, MICA, MICB
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013153 Life Technologies
LS14578880
25μg Each for $100.05
5013154 Life Technologies
LS14578882
100μg Each for $158.05
Specifications

Description

The 6D4 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I chain-related (MIC), MICA and MICB proteins. MICA and MICB are related proteins of 83% amino acid similarity, and show homology with classical human leukocyte antigen (HLA) molecules. The structure of MICA and MICB are similar to classical HLA class I chains, however they do not bind β2 microglobulin or bind peptide typical of HLA class I. MICA and MICB are expressed on the cell surface of endothelial cells, fibroblasts, gastric epithelium and PHA-stimulated T cells, and act as a ligand for NKGD2 expressed on the surface of NK cells, γδ T cells and αβ CD8+ T cells. There is evidence to suggest that human cytomegalovirus (HCMV) subverts NK cell detection by inhibiting the function of MICB. Furthermore, MICA and MICB expression has been detected in several epithelial tumours isolated from breast, lung, ovary, prostate, colon and kidney.
Description & Specifications

Specifications

MICA/B
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
6D4
MICA/MICB, MICA, MICB
Flow Cytometry,Functional Assay,Immunohistochemistry,Immunoprecipitation
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL