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MICA/B Mouse anti-Human, Clone: 6D4, eBioscience™

Mouse Monoclonal Antibody

$100.05 - $158.05

Specifications

Antigen MICA/B
Clone 6D4
Host Species Mouse
Gene Alias MICA/MICB, MICA, MICB
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013153

 
affymetrix
14-5788-80
25μg Each for $100.05

5013154

 
affymetrix
14-5788-82
100μg Each for $158.05
Description & Specifications

Specifications

Antigen MICA/B
Clone 6D4
Host Species Mouse
Gene Alias MICA/MICB, MICA, MICB
Species Reactivity Human
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 6D4 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I chain-related (MIC), MICA and MICB proteins. MICA and MICB are related proteins of 83% amino acid similarity, and show homology with classical human leukocyte antigen (HLA) molecules. The structure of MICA and MICB are similar to classical HLA class I chains, however they do not bind β2 microglobulin or bind peptide typical of HLA class I. MICA and MICB are expressed on the cell surface of endothelial cells, fibroblasts, gastric epithelium and PHA-stimulated T cells, and act as a ligand for NKGD2 expressed on the surface of NK cells, γδ T cells and αβ CD8+ T cells. There is evidence to suggest that human cytomegalovirus (HCMV) subverts NK cell detection by inhibiting the function of MICB. Furthermore, MICA and MICB expression has been detected in several epithelial tumours isolated from breast, lung, ovary, prostate, colon and kidney.