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Thermo Scientific™ Lab Vision™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

$250.86 - $1,496.37

Specifications

Antigen MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Clone MT 3.1
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Applications Immunohistochemistry (Paraffin)
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

MS470B

 
thermo scientific™ lab vision™
MS-470-B
Biotinylated Ab with BSA and Azide 1mL Each for $1,496.37

MS470B0

 
thermo scientific™ lab vision™
MS-470-B0
Biotinylated Ab with BSA and Azide 100µL Each for $339.76

MS470B1

 
thermo scientific™ lab vision™
MS-470-B1
Biotinylated Ab with BSA and Azide 500µL Each for $933.47

MS470P

 
thermo scientific™ lab vision™
MS-470-P
Purified Ab with BSA and Azide 1mL Each for $1,192.14

MS470P0

 
thermo scientific™ lab vision™
MS-470-P0
Purified Ab with BSA and Azide 100µL Each for $250.86

MS470P1

 
thermo scientific™ lab vision™
MS-470-P1
Purified Ab with BSA and Azide 500µL Each for $715.67

MS470P1ABX

 
thermo scientific™ lab vision™
MS470P1ABX
Ab without BSA/Azide (Frozen) 100µL Each for $788.73

MS470PABX

 
thermo scientific™ lab vision™
MS-470-PABX
Ab without BSA/Azide (Frozen) 200µL Each for $1,303.14

MS470R7

 
thermo scientific™ lab vision™
MS-470-R7
Ready-to-use for IHC (UVLP) 7mL Each for $770.41
Description & Specifications

Specifications

Antigen MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Clone MT 3.1
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Classification Monoclonal
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Host Species Mouse
Regulatory Status RUO
Research Discipline Enzyme
Type Primary
Immunogen Purified recombinant human MGMT protein
Isotype IgG1

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.

Host Species: Mouse

Clone: MT 3.1

Isotype: IgG1

Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.

Epitope: aa 8-221

Immunogen: Purified recombinant human MGMT protein

Molecular Weight: 25kDa

Positive Control: Raji cells, Colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO