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Thermo Scientific™ Lab Vision™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

$269.86 - $1,608.84

Specifications

Antigen MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Clone MT 3.1
Applications Immunohistochemistry (Paraffin),Western Blotting,Immunohistochemistry (Paraffin),Western Blotting
Classification Monoclonal
Host Species Murine
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Products ${productFamilyLength}
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
MS470B Thermo Scientific™ Lab Vision™
MS470B
Biotinylated Ab with BSA and Azide 1mL Each for $1,608.84
MS470B0 Thermo Scientific™ Lab Vision™
MS470B0
Biotinylated Ab with BSA and Azide 100μL Each for $365.45
MS470B1 Thermo Scientific™ Lab Vision™
MS470B1
Biotinylated Ab with BSA and Azide 500μL Each for $1,003.67
MS470P Thermo Scientific™ Lab Vision™
MS470P
Purified Ab with BSA and Azide 1mL Each for $1,281.90
MS470P0 Thermo Scientific™ Lab Vision™
MS470P0
Purified Ab with BSA and Azide 100μL Each for $269.86
MS470P1 Thermo Scientific™ Lab Vision™
MS470P1
Purified Ab with BSA and Azide 500μL Each for $769.63
MS470P1ABX Thermo Scientific™ Lab Vision™
MS470P1ABX
Ab without BSA/Azide (Frozen) 100μL Each for $848.04
MS470PABX Thermo Scientific™ Lab Vision™
MS470PABX
Ab without BSA/Azide (Frozen) 200μL Each for $1,401.31
MS470R7 Thermo Scientific™ Lab Vision™
MS470R7
Ready-to-use for IHC (UVLP) 7mL Each for $828.33
Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.

Host Species: Mouse

Clone: MT 3.1

Isotype: IgG1

Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.

Epitope: aa 8-221

Immunogen: Purified recombinant human MGMT protein

Molecular Weight: 25kDa

Positive Control: Raji cells, Colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Immunohistochemistry (Paraffin),Western Blotting,Immunohistochemistry (Paraffin),Western Blotting
Murine
Enzyme
Purified recombinant human MGMT protein
MT 3.1
Monoclonal
RUO
Primary
IgG1