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Thermo Scientific™ Lab Vision™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS470P1ABX

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Catalog No. MS470P1ABX


 

Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody.

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.

Host Species: Mouse

Clone: MT 3.1

Isotype: IgG1

Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.

Epitope: aa 8-221

Immunogen: Purified recombinant human MGMT protein

Molecular Weight: 25kDa

Positive Control: Raji cells, Colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Monoclonal
1mg/mL
Hamster,Human,Mouse,Rat
Ab without BSA/Azide (Frozen)
Purified recombinant human MGMT protein
100μL
Enzyme
Monoclonal
Immunohistochemistry (Paraffin),Western Blotting
MT 3.1
Unlabeled
Concentrated
Murine
IgG1
RUO
Primary
Hamster,Human,Murine,Rat