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Methotrexate, Fisher BioReagents


Quantity 10mg
Packaging Amber Glass

Manufacturer: fisher scientific company  BP266510

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Catalog No. BP266510

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Description & Specifications

Chemical Identifiers

Organic Volatile Impurities Meets Requirements
Packaging Amber Glass
Ignition Residue 0.1% max.
Purity Pass Test
Specific Rotation +19.0 to +24.0° (+ or -)
Water 12% Max.
Decomposition Information >195°C
Color Yellow
Melting Point 195°C / 383°F
Quantity 10mg
Chemical Name or Material Methotrexate
CAS 59-05-2
Physical Form Powder; Solid
Assay 98.0 to 102.0%
Assay Percent Range 98.0 to 102.0 %
Molecular Formula C20H22N8O5
Formula Weight 454.44g/mol
Merck Index 15, 6057
Synonym Amethopterin
ChemAlert Storage Symbol Blue
Health Hazard 2 DANGER!
Health Hazard 3 Emergency Overview
Toxic if swallowed. This substance has caused adverse reproductive and fetal effects in humans. May cause heritable genetic damage. Liver and kidney injuries may occur. Hygroscopic. Use only under a chemical fume hood. Use personal protective equipment. Do not breathe dust. Do not get in eyes, on skin, or on clothing. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention.

NFPA

Health:3
Flammability:0
Instability:1
Recommended Storage 0°C
DOT Information DOT Class 6.1, : Poison

Specifications

Chemical Name or Material Methotrexate
CAS 59-05-2
Physical Form Powder; Solid
Assay 98.0 to 102.0%
Assay Percent Range 98.0 to 102.0 %
Molecular Formula C20H22N8O5
Formula Weight 454.44g/mol
Synonym Amethopterin

  • Inhibitor of DNA and RNA synthesis
  • Inhibits the enzyme responsible for synthesizing the folic acid derivative that is necessary for purine and pyrimidine synthesis
  • The lack of purines and pyrimidines  impacts the synthesis of DNA, RNA, and proteins
  • Referenced for use in antitumor studies and other studies of biological pathways
  • Intended for research use only

Accessories
 

Emergency Overview
Toxic if swallowed. This substance has caused adverse reproductive and fetal effects in humans. May cause heritable genetic damage. Liver and kidney injuries may occur. Hygroscopic. Use only under a chemical fume hood. Use personal protective equipment. Do not breathe dust. Do not get in eyes, on skin, or on clothing. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention.

NFPA

Health:3
Flammability:0
Instability:1

DANGER!

0°C

SDS & Safety Documents