Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.
Miscible with alcohol, ether and organic solvents. Immiscible with water.
Moisture sensitive. Store in a cool place. Incompatible with strong bases, oxidizing agents and alcohols. It is a lachrymator and reacts with water.
Safety and Handling
GHS H Statement
GHS P Statement
DOTInformation : Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: METHANESULFONYL CHLORIDE
RTECSNumber : PB2790000
TSCA : TSCA
storageNote1 : Moisture Sensitive