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MerTK Mouse anti-Human, PE, Clone: HMER5DS, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $491.55

Specifications

Antigen MerTK
Clone HMER5DS
Host Species Mouse
Gene Alias Mer, c-mer
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122416

 
affymetrix
12904342
100 tests Each for $491.55

501129299

 
affymetrix
12-9043-41
25 tests Pack for $201.55
Description & Specifications

Specifications

Antigen MerTK
Clone HMER5DS
Host Species Mouse
Gene Alias Mer, c-mer
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This HMER5DS antibody recognizes human MerTK, known also as Mer or c-mer, a 170-210kDa member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3. MerTK is expressed on a subset of anti-inflammatory macrophages and is involved in the removal of apoptotic cells. This process relies on two soluble ligands of Mer,TK Protein S and Gas6, that coat the surface of cells undergoing apoptosis. Upon binding these ligands, MerTK undergoes autophosphorylation at multiple tyrosine residues that activate the PI3K and Akt pathways. This results in the phagocytosis of target cells and also the direct inhibition of TLR-induced production of pro-inflammatory cytokines by the phagocytes. Mer may also function as a putative entry receptor for filoviruses. Deficiency of MerTK causes general autoimmunity, inflammation, and accumulation of apoptotic bodies. MerTK can be released from the cell surface by metalloproteinases, and this process is significantly enhanced when macrophages are stimulated, e.g. with LPS. MerTK is often expressed on malignant cells, and may be implicated in immune evasion.