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MD-2 Mouse anti-Human, Clone: 9B4, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $361.05

Specifications

Antigen MD-2
Clone 9B4
Host Species Mouse
Gene Alias MD2; Toll-like Receptor
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013883

 
affymetrix
14-9928-80
25μg Each for $158.05

5013884

 
affymetrix
14-9928-82
100μg Each for $361.05
Description & Specifications

Specifications

Antigen MD-2
Clone 9B4
Host Species Mouse
Gene Alias MD2; Toll-like Receptor
Species Reactivity Human
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 9B4 antibody reacts with human MD-2, an approximately 30kDa molecule, which physically associates with the extracellular domain of TLR4. MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4 since in MD-2(-/-) embryonic fibroblasts, TLR4 was not able to reach the plasma membrane and predominantly resided in the Golgi apparatus, whereas TLR4 was distributed at the leading edge surface of cells in wild-type embryonic fibroblasts. MD-2(-/-) mice do not respond to LPS, do survive endotoxic shock but are susceptible to Salmonella typhimurium infection.