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MCPT-1 (mMCP-1) Rat anti-Mouse, Clone: RF6.1, eBioscience™

Rat Monoclonal Antibody

$114.55 - $259.55

Specifications

Antigen MCPT-1 (mMCP-1)
Clone RF6.1
Host Species Rat
Gene Alias Mast cell protease-1
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245559

 
affymetrix
14550380
25μg Each for $114.55

50245560

 
affymetrix
14550382
100μg Each for $259.55
Description & Specifications

Specifications

Antigen MCPT-1 (mMCP-1)
Clone RF6.1
Host Species Rat
Gene Alias Mast cell protease-1
Species Reactivity Mouse
Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody RF6 recognized MCPT-1 (Mast Cell Protease-1) which is a ß-chymase, a type of serine protease stored and secreted in a tissue-specific manner by mucosal mast cells. MCPT-1 is a chymotryptic protease, referring to its ability to cleave proteins and peptides after an aromatic amino acid. It shares 74% sequence homology with its rat counterpart, rat Mast Cell Protease-II (rMCP-II) and has no direct human counterpart.

MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium. Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection. It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection. Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions. The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCP-II, possibly by cleaving the proteins at tight junctions between cells.