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Mcl-1 Mouse anti-Human, Mouse, Clone: LVUBKM, eBioscience™

Mouse Monoclonal Antibody

$159.72 - $389.40

Specifications

Antigen Mcl-1
Clone LVUBKM
Host Species Murine
Gene Alias myeloid cell leukemia sequence 1
Applications Flow Cytometry (Intracellular Staining),Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122754 Life Technologies
LS14904782
100μg Each for $389.40
501122753 Life Technologies
LS14904780
25μg Each for $159.72
Specifications

Description

This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.
Description & Specifications

Specifications

Mcl-1
Murine
Flow Cytometry (Intracellular Staining),Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
LVUBKM
myeloid cell leukemia sequence 1
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer