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Mcl-1 Mouse anti-Human, Mouse, Alexa Fluor 488, Clone: LVUBKM, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $477.05

Specifications

Antigen Mcl-1
Clone LVUBKM
Host Species Mouse
Gene Alias myeloid cell leukemia sequence 1
Species Reactivity Human, Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124614

 
affymetrix
53904741
25 tests Each for $201.55

501124615

 
affymetrix
53904742
100 tests Each for $477.05
Description & Specifications

Specifications

Antigen Mcl-1
Clone LVUBKM
Host Species Mouse
Gene Alias myeloid cell leukemia sequence 1
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.