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Thermo Scientific™ Lab Vision™ Mcl-1 Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

$272.57 - $1,453.06

Specifications

Antigen Mcl-1 Ab-1
Clone RC13
Applications Immunoprecipitation,Western Blotting,Immunoprecipitation,Western Blotting
Classification Monoclonal
Format Concentrated
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity  
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity  
MS681B Thermo Scientific™ Lab Vision™
MS681B
400ug/mL Biotin 1mL Each for $1,453.06
MS681B0 Thermo Scientific™ Lab Vision™
MS681B0
400ug/mL Biotin 100μL Each for $365.12
MS681B1 Thermo Scientific™ Lab Vision™
MS681B1
400ug/mL Biotin 500μL Each for $972.16
MS681P Thermo Scientific™ Lab Vision™
MS681P
400ug/mL Unlabeled 1mL Each for $1,116.41
MS681P0 Thermo Scientific™ Lab Vision™
MS681P0
400ug/mL Unlabeled 100μL Each for $272.57
MS681P1 Thermo Scientific™ Lab Vision™
MS681P1
400ug/mL Unlabeled 500μL Each for $771.10
MS681P1ABX Thermo Scientific™ Lab Vision™
MS681P1ABX
1mg/mL Unlabeled 100μL Each for $819.76
MS681PABX Thermo Scientific™ Lab Vision™
MS681PABX
1mg/mL Unlabeled 200μL Each for $1,176.55
Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.

Host Species: Mouse

Clone: RC13

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: aa 1-327

Immunogen: Recombinant human Mcl-1 protein corresponding to aa 1-327

Molecular Weight: 42kDa

Positive Control: Raji cells, Spleen or tonsil

Cellular Localization: Predominantly nuclear; occasionally cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Mcl-1 Ab-1
Immunoprecipitation,Western Blotting,Immunoprecipitation,Western Blotting
Concentrated
RUO
Primary
IgG2a kappa
RC13
Monoclonal
Murine
Apoptosis
Recombinant human Mcl-1 protein corresponding to aa 1-327