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Thermo Scientific™ Lab Vision™ Mcl-1 Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS681P1ABX

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Catalog No. MS681P1ABX


 

Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.

Host Species: Mouse

Clone: RC13

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: aa 1-327

Immunogen: Recombinant human Mcl-1 protein corresponding to aa 1-327

Molecular Weight: 42kDa

Positive Control: Raji cells, Spleen or tonsil

Cellular Localization: Predominantly nuclear; occasionally cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Mcl-1 Ab-1
Monoclonal
1mg/mL
Human
Murine
IgG2a kappa
RUO
Primary
Human
Immunoprecipitation,Western Blotting
RC13
Unlabeled
Concentrated
Recombinant human Mcl-1 protein corresponding to aa 1-327
100μL
Apoptosis
Monoclonal