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Thermo Scientific™ Lab Vision™ Mcl-1 Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS681P1ABX

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Catalog No. MS681P1ABX

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Description & Specifications

Specifications

Antigen Mcl-1 Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone RC13
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Murine
Immunogen Recombinant human Mcl-1 protein corresponding to aa 1-327
Isotype IgG2a kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

Ensure accurate, reproducible results in immunohistochemistry experiments with the Thermo Scientific™ Mcl-1 Ab-1, Mouse Monoclonal Antibody.

Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.

Host Species: Mouse

Clone: RC13

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: aa 1-327

Immunogen: Recombinant human Mcl-1 protein corresponding to aa 1-327

Molecular Weight: 42kDa

Positive Control: Raji cells, Spleen or tonsil

Cellular Localization: Predominantly nuclear; occasionally cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO