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MASH1 Mouse anti-Mouse, Rat, Clone: 24B72D11, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $317.55

Specifications

Antigen MASH1
Clone 24B72D11
Host Species Mouse
Gene Alias Mammalian achaete-scute homolog 1
Species Reactivity Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122693

 
affymetrix
14579480
25μg Each for $129.05

501122694

 
affymetrix
14579482
100μg Each for $317.55
Description & Specifications

Specifications

Antigen MASH1
Clone 24B72D11
Host Species Mouse
Gene Alias Mammalian achaete-scute homolog 1
Species Reactivity Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 24B72D11 recognizes mouse and rat Mammalian achaete-scute homolog 1 (MASH1), a 34kDa basic helix-loop-helix (bHLH) transcription factor. MASH1, like family members Olig2 and Ngn2, is expressed in progenitor cells throughout the nervous system and retina and is a key regulator of cell fate specification. Expression of MASH1 is regulated by the Delta/Notch1 pathway through direct binding of Hes1 to MASH1 as well as competitive binding to MASH1 hetero-dimerizing proteins. At a transcriptional level, MASH1 expression is controlled by notch-mediated regulation of sox2, which binds to the MASH1 promoter region up-regulating expression. MASH1 has been implicated in the formation of multiple neural cell types including dopaminergic, serotonergic, glutaminergic and GABAergic neurons. Overexpression of MASH1 has been shown in small cell lung carcinoma and medullary thyroid cancer.