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MASH1 Mouse anti-Mouse, Rat, Clone: 24B72D11, eBioscience™

Mouse Monoclonal Antibody

$120.12 - $294.36

Specifications

Antigen MASH1
Clone 24B72D11
Host Species Murine
Gene Alias Mammalian achaete-scute homolog 1
Species Reactivity Mouse, Rat
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122693 Life Technologies
LS14579480
25μg Each for $120.12
501122694 Life Technologies
LS14579482
100μg Each for $294.36
Specifications

Description

The monoclonal antibody 24B72D11 recognizes mouse and rat Mammalian achaete-scute homolog 1 (MASH1), a 34kDa basic helix-loop-helix (bHLH) transcription factor. MASH1, like family members Olig2 and Ngn2, is expressed in progenitor cells throughout the nervous system and retina and is a key regulator of cell fate specification. Expression of MASH1 is regulated by the Delta/Notch1 pathway through direct binding of Hes1 to MASH1 as well as competitive binding to MASH1 hetero-dimerizing proteins. At a transcriptional level, MASH1 expression is controlled by notch-mediated regulation of sox2, which binds to the MASH1 promoter region up-regulating expression. MASH1 has been implicated in the formation of multiple neural cell types including dopaminergic, serotonergic, glutaminergic and GABAergic neurons. Overexpression of MASH1 has been shown in small cell lung carcinoma and medullary thyroid cancer.
Description & Specifications

Specifications

MASH1
Murine
Mouse, Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
24B72D11
Mammalian achaete-scute homolog 1
Immunocytochemistry,Immunohistochemistry (Frozen),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL