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Invitrogen™ Human MAP4K3 (GLK), GST Tag Recombinant Protein 
Human MAP4K3 (GLK), GST Tag Recombinant Protein
Supplier: Invitrogen™ PV6351
Description
MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-Θ, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-Θ, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Specifications
| 69.6 kDa | |
| MAP4K3, MAPKKKK3, MEKKK3, RAB8IPL1 | |
| Human | |
| GST Tag | |
| Serine/Threonine Kinase | |
| Kinases & Inhibitors | |
| Serine/Threonine Kinases |
| 1mg | |
| aa 1-380 | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
|
| Baculovirus | |
| Recombinant, Fragment |