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Thermo Scientific™ MAbPac™ SCX-10 LC Columns


Use these strong cation-exchange columns for high-resolution, high efficiency analysis of monoclonal antibodies (mAbs) and associated variants.

Manufacturer: thermo scientific™  074625

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 Disclaimers

Limited warranty period: Subject to all warranty requirements and exclusions set out in our Terms and Conditions of Sale, this product is warranted from the date we ship the product and for ninety (90) days thereafter. Disclaimer to internal research use restriction: Any restrictions on the purchaser to utilize the product(s) for internal research purposes only does not apply to the product(s) on the web pages associated with this statement.

Catalog No. DX074625

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Description & Specifications

Specifications

Column Format Analytical Column
Diameter (Metric) 4mm
For Use With Separation and Analysis of Monoclonal Antibody Variants
Column Type Ion Exchange
Flow Rate 0.2 to 2.0mL/min.
Packing Material Spherical, non-porous polymer
Packing Material DVB
Temperature 60°C
Particle Size 10µm
Pore Size Non-porous
pH 2 to 12
Stationary Phase Sulfonate
Solvents 50% Acetonitrile
Surface Area -
Length (Metric) 250mm
Technique Monoclonal Antibody/Cation Exchange
Detergent Compatibility Nonionic, Anionic or Zwitterionic
Carbon Load -
Temperature Range Ambient - 60°C
Max. Pressure 3000psi
Type Analytical Column
Buffers Sodium or Potassium Salts of Phosphate, MES
Ion Exchange Group Sulfonic Acid
USP Type N/A
Endcapped -

Use Thermo Scientific™ MAbPac™ SCX-10 LC Columns for high-resolution, high efficiency analysis of monoclonal antibodies (mAbs) and associated variants. The unique nonporous pellicular resin provides the resolving power to separate mAb variants that differ by as little as one charged residue. A hydrophilic layer surrounds the polymeric beads and eliminates hydrophobic interactions with the resin, resulting in very efficient peaks. A proprietary grafted cation-exchange surface provides pH selectivity control for high-resolution separations.

Superior Performance for mAb Variant Analysis

  • Exceptionally high resolution for mAb variants
  • Ideal for characterization and quality control assessment of mAbs
  • Well-suited for stability studies, mAb therapeutic method development and high-throughput screening
  •  Unmatched column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing
  • Meets the regulatory requirements for biopharmaceutical characterization
Multiple Sizes Available
  • Available in 3, 5 and 10μm particle sizes in standard and UHPLC formats
  • Smaller-particle-size columns provide the same resolution as the 10μm columns, but with significantly faster analysis time