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Lyve-1 Rat anti-Mouse, eFluor 660, Clone: ALY7, eBioscience™

Rat Monoclonal Antibody

$187.05 - $462.55

Specifications

Antigen Lyve-1
Clone ALY7
Host Species Rat
Gene Alias Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016437

 
affymetrix
50044380
25μg Each for $187.05

5016438

 
affymetrix
50044382
100μg Each for $462.55
Description & Specifications

Specifications

Antigen Lyve-1
Clone ALY7
Host Species Rat
Gene Alias Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Species Reactivity Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody ALY7 recognizes mouse LYVE-1, a transmembrane glycoprotein with similarity to CD44. The extracellular domain contains a conserved hyaluronan binding domain also found in CD44. Expression is found on lymphatic and liver endothelial cells and some populations of macrophages. The lymphatic system is responsible for transporting proteins and cells (especially dendritic cells) to tissues throughout the body, thereby acting as immune surveyors. LYVE-1 is one characteristic protein, along with podoplanin, PROX-1, Tie-2 and VEGFR-3, that is expressed on lymphatic endothelial cells (LECS). The ligand for LYVE-1 is hyaluronan, a large mucopolysaccharide. Although LYVE-1 can bind hyaluronan in vitro, the site for ligand binding in vivo is masked by sialyated O-linked glycan chains. It is postulated that binding to ligand requires modification/unmasking to expose the binding site. The development and remodeling of the endothelium after injury is an area of extensive study. When transplanted, hematopoietic stem cells (HSCs) can give rise to LECs that integrate into the endothelium in normal and metastatic tissue.