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Invitrogen™ LYN A Recombinant Human Protein, N-GST tag DFS Item

LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue.

Manufacturer:  Invitrogen™ LSPV6448

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Catalog No. PV6448



Description

Description

LYN is a protein-coding gene and is associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of this gene is FRK. The full length LYN A protein enables researchers to study important mechanisms underlying disease.

  • Increase disease relevance by interrogating a purified and active full-length LYN A reagent
  • Uncover novel compounds or hits specific to the full length form
  • Advance your research using the full-length protein and validated assays
  • Assay Platforms: LanthaScreen™ TR-FRET Kinase Activity Assay, LanthaScreen™ Eu Kinase Binding Assay, and Z’-LYTE™ Kinase Activity Assay
Specifications

Specifications

NP_002341.1
81kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.

Suspended in: 50 nM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
JTK8, FLJ26625
Insect
Human
GST Tag
Z´-LYTE™ Kinase Assays|Target & Lead Identification & Validation|Kinase Biology|Biochemical Kinase Assays|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
10μg
Full Length
Kinase Assay
SRC Kinase Family
Yes
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