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LRRK2 [I2020T] Human Protein DFS Item

LRRK2 [I2020T] Human Protein

Manufacturer:  Life Technologies LSPV5854

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Catalog No. PV5854



Description

Description

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease, including the I2020T mutation in the kinase catalytic domain.

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  • Specifications

    Specifications

    NP_940980.2
    Pharma and biopharma, protein assays and analysis, target and lead identification and validation
    Frozen
    LRRK2 [I2020T] Human Protein
    10μg
    For research use only. Not for use in diagnostic procedures
    Serine/threonine kinase
    LRRK2 [I2020T] Human Protein
    Kinase assay
    Baculovirus
    Amino acids 970-2527
    21nmoles of phosphate transferred to ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2.08μg/mL
    GST Tag
    0.28mg/mL
    Frozen
    205kDa
    85% by SDS-PAGE
    –80°C
    1 Each
    LRRK2 I2020T
    LRRK2 I2020T was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β- glycerophosphate, 2mM DTT, 0.02% Polysorbate 20, 100μM ATP, 250μM ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) and trace [32P]-γ-ATP for 10 minutes at 30°C
    Kinase and inhibitors
    LRRK
    LRRK2 [I2020T] Human Protein
    Human
    Documents

    For Research Use Only. Not for use in diagnostic procedures.