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LRP/MVP (Major Vault Protein) Ab-2 Mouse Monoclonal Antibody, Epredia™
Recommended for a variety of techniques, Epredia™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.
Supplier: Thermo Fisher Scientific MS664P1
Description
Major vault protein (MVP) is identical to lung-resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung-resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cell lines indicating a poor response to chemotherapy.Host Species: Mouse
Clone: 1032
Isotype: IgG1/κ
Species Reactivity: Human and Rat. Others not known.
Epitope: Not determined
Immunogen: Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells
Molecular Weight: 104-110kDa
Positive Control: SKBR-3 cells, Breast tumors
Cellular Localization: Cytoplasmic
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunoprecipitation (Native verified)
- Gel Supershift
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| LRP/MVP (Major Vault Protein) Ab-2 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 500 μL | |
| Cancer and Tumor Biology | |
| Human, Rat | |
| IgG2a κ |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 1032 | |
| Unconjugated | |
| Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells | |
| RUO | |
| Primary | |
| Concentrated |