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Thermo Scientific™ Lab Vision™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody


Recommended for a variety of techniques, Thermo Scientific™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer: thermo scientific™ lab vision™  MS664P1ABX

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Catalog No. MS664P1ABX

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Description & Specifications

Specifications

Antigen LRP/MVP (Major Vault Protein) Ab-2
Immunogen Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Clone 1032
Format Concentrated
Host Species Mouse
Cross Reactivity Human
Cross Reactivity Rat
Formulation Ab without BSA/Azide (Frozen)
Research Discipline Cancer and Tumor Biology
Type Primary
Classification Monoclonal
Concentration 1mg/mL
Conjugate Unlabeled

Recommended for a variety of techniques, Thermo Scientific™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.

Major vault protein (MVP) is identical to lung-resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung-resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cell lines indicating a poor response to chemotherapy.

Host Species: Mouse

Clone: 1032

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells

Molecular Weight: 104-110kDa

Positive Control: SKBR-3 cells, Breast tumors

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)
  • Gel Supershift
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO