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Thermo Scientific™ Lab Vision™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody

Recommended for a variety of techniques, Thermo Scientific™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS664P1ABX

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Catalog No. MS664P1ABX


 

Specifications

Description

Recommended for a variety of techniques, Thermo Scientific™ LRP/MVP (Major Vault Protein) Ab-2, Mouse Monoclonal Antibody provides accurate, reproducible results.

Major vault protein (MVP) is identical to lung-resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung-resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cell lines indicating a poor response to chemotherapy.

Host Species: Mouse

Clone: 1032

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells

Molecular Weight: 104-110kDa

Positive Control: SKBR-3 cells, Breast tumors

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native verified)
  • Gel Supershift
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

LRP/MVP (Major Vault Protein) Ab-2
Monoclonal
1mg/mL
Ab without BSA/Azide (Frozen)
Murine
IgG2a kappa
RUO
Primary
Human,Rat
Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting
1032
Unlabeled
Concentrated
Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells
100μL
Cancer and Tumor Biology
Monoclonal