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Alfa Aesar™ Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle

Chemical Identifiers

Chemical Name or Material Lithium bis(trimethylsilyl)amide
CAS 4039-32-1
Name Note packaged in resealable septum cap bottle
Molecular Formula C6H18LiNSi2
Linear Formula [(CH3)3Si]2NLi
Formula Weight 167.33
MDL Number MFCD00008261
UN Number UN2924
Beilstein 8136861
Synonym LHMDS; Lithium hexamethyldisilazide
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAL15012AP

  SDS
alfa aesar™
L15012AP
500mL CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Formula Weight 167.33
Chemical Name or Material Lithium bis(trimethylsilyl)amide
CAS 4039-32-1
Health Hazard 3 GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Beilstein 8136861
Name Note packaged in resealable septum cap bottle
TSCA TSCA
Linear Formula [(CH3)3Si]2NLi
MDL Number MFCD00008261
UN Number UN2924
Flash Point −17°C (1°F)
Health Hazard 1 Danger
Quantity 500mL
Health Hazard 2 GHS H Statement
H225-H314-H351-H335
Highly flammable liquid and vapor.
Causes severe skin burns and eye damage.
Suspected of causing cancer.
May cause respiratory irritation.
Concentration 20% (≈1.06M) soln. in THF/ethylbenzene
Synonym LHMDS; Lithium hexamethyldisilazide
DOT Information Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
Molecular Formula C6H18LiNSi2

Applications
Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.

Solubility
Reacts with water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Incompatible with oxidizing agents.

Safety and Handling

Danger

GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H225-H314-H351-H335
Highly flammable liquid and vapor.
Causes severe skin burns and eye damage.
Suspected of causing cancer.
May cause respiratory irritation.