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Alfa Aesar™ Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle

Chemical Identifiers

Chemical Name or Material Lithium bis(trimethylsilyl)amide
CAS 4039-32-1
Name Note packaged in resealable septum cap bottle
Molecular Formula C6H18LiNSi2
Linear Formula [(CH3)3Si]2NLi
Formula Weight 167.33g/mol
MDL Number MFCD00008261
UN Number UN2924
Beilstein 8136861
Synonym LHMDS; Lithium hexamethyldisilazide
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAL15012AP

 
alfa aesar™
L15012-AP
500mL CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Concentration 20% (≈1.06M) soln. in THF/ethylbenzene
Quantity 500mL
Flash Point −17°C (1°F)
Chemical Name or Material Lithium bis(trimethylsilyl)amide
Name Note packaged in resealable septum cap bottle
CAS 4039-32-1
Molecular Formula C6H18LiNSi2
Linear Formula [(CH3)3Si]2NLi
Formula Weight 167.33g/mol
MDL Number MFCD00008261
UN Number UN2924
Beilstein 8136861
Synonym LHMDS; Lithium hexamethyldisilazide
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H225-H314-H351-H335
Highly flammable liquid and vapor.
Causes severe skin burns and eye damage.
Suspected of causing cancer.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
TSCA TSCA

Applications
Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.

Solubility
Reacts with water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Incompatible with oxidizing agents.

Safety and Handling

Danger

GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H225-H314-H351-H335
Highly flammable liquid and vapor.
Causes severe skin burns and eye damage.
Suspected of causing cancer.
May cause respiratory irritation.