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LAT Mouse anti-Human, Clone: LAT.10-17 (10-17), eBioscience™

Mouse Monoclonal Antibody

$143.55 - $275.88

Specifications

Antigen LAT
Clone LAT.10-17 (10-17)
Host Species Murine
Gene Alias Linker for activation of T-cells
Applications Immunoprecipitation,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122896 Life Technologies
LS14996780
25μg Each for $143.55
5013936 Life Technologies
LS14996782
100μg Each for $275.88
Specifications

Description

This LAT.10-17 (10-17) monoclonal antibody reacts with human Linker for Activation of T cells (LAT), which is essential for T cell receptor (TCR)-mediated signal transduction. Characterized as an integral transmembrane protein, this ∽37kDa molecule does not possess a true extracellular domain. Upon TCR/CD3 engagement, LAT localizes to lipid rafts and is tyrosine phosphorylated by ZAP-70, leading to the recruitment and activation of other downstream signaling molecules such as Grb-2, PLCγ, and PI3K. This adapter molecule has been shown to be required for T cell activation, as well as thymocyte and T regulatory cell development. In humans, LAT is expressed on peripheral blood lymphocytes, lymph nodes, and tonsil. Studies in mice have shown that LAT is expressed in thymocytes, T cells, mast cells, natural killer cells, megakaryocytes, platelets, and early B cells. This antibody does not crossreact with the mouse antigen.
Description & Specifications

Specifications

LAT
Murine
Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
LAT.10-17 (10-17)
Linker for activation of T-cells
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer