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LAP Mouse anti-Mouse, PE-Cy7, Clone: TW7-16B4, eBioscience™

Mouse Monoclonal Antibody

$166.75 - $419.05

Specifications

Antigen LAP
Clone TW7-16B4
Host Species Mouse
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123461

 
affymetrix
25982180
25μg Each for $166.75

501123462

 
affymetrix
25982182
100μg Each for $419.05
Description & Specifications

Specifications

Antigen LAP
Clone TW7-16B4
Host Species Mouse
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The TW7-16B4 monoclonal antibody reacts with mouse latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.