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LAP Mouse anti-Human, PE-Cy7, Clone: FNLAP, eBioscience™

Mouse Monoclonal Antibody

$196.68 - $460.68

Specifications

Antigen LAP
Clone FNLAP
Host Species Murine
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245759 Life Technologies
LS25982941
25 Tests Each for $196.68
50245760 Life Technologies
LS25982942
100 Tests Each for $460.68
Specifications

Description

The FNLAP monoclonal antibody reacts with human latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.
Description & Specifications

Specifications

LAP
Murine
Flow Cytometry
PE-Cy7
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
5μL (0.25μg)/test
FNLAP
Pro-TGF beta 1, LAP/TGF beta 1
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer