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LAP Mouse anti-Human, eFluor 450, Clone: FNLAP, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $506.05

Specifications

Antigen LAP
Clone FNLAP
Host Species Mouse
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124230

 
affymetrix
48982941
25 tests Each for $216.05

501124231

 
affymetrix
48982942
100 tests Each for $506.05
Description & Specifications

Specifications

Antigen LAP
Clone FNLAP
Host Species Mouse
Gene Alias Pro-TGF beta 1, LAP/TGF beta 1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

The FNLAP monoclonal antibody reacts with human latency associated peptide (LAP, pro-TGF beta 1, LAP/TGF beta 1). Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. TGF beta is synthesized as a precursor that contains LAP at the N-terminus and mature TGF beta at the C-terminus. Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. LAP is secreted and can be found in the extracellular matrix. In addition, LAP can also be expressed on platelets and activated regulatory T cells. It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells.