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Lamin A/C Mouse, Alexa Fluor 488, Clone: 4A7, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen Lamin A/C
Clone 4A7
Host Species Mouse
Gene Alias LMNA, LMNC
Species Reactivity Hamster, Human, Mouse, Rabbit
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124626

 
affymetrix
53968880
25μg Each for $172.55

501124627

 
affymetrix
53968882
100μg Each for $433.55
Description & Specifications

Specifications

Antigen Lamin A/C
Clone 4A7
Host Species Mouse
Gene Alias LMNA, LMNC
Species Reactivity Hamster, Human, Mouse, Rabbit
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 4A7 recognizes human, mouse, rabbit and hamster lamin A/C. Lamins are nuclear intermediate filament proteins that provide framework for the nuclear envelope, maintain cell morphology, and protect the nucleus from mechanical, thermal, and oxidative stresses. Lamins also play a role in nuclear assembly, chromatin organization, DNA replication, RNA transcription, cell signaling, and apoptosis. Lamin C is a splice variant of Lamin A and both are A-type lamins. Lamin A and C are crucial for skeletal and cardiac development and function. Defects in A-type lamins result in cardiomyopathy, muscular dystrophy, peripheral neuropathy, lipodystrophy, restrictive dermopathy, and progeroid disorders.