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Epredia™ Lab Vision™ Retinoblastoma (Rb) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, biotinylated, BSA and azide
Provide accurate, reproducible results with the Epredia™ Retinoblastoma (Rb) Ab-1, Mouse Monoclonal Antibody.
$643.00 - $1,075.33
Specifications
| Antigen | Retinoblastoma (Rb) Ab-1 |
|---|---|
| Clone | 1F8; same as Rb1 |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Host Species | Mouse |
| Catalog Number | Mfr. No. | Form | Conjugate | Quantity | Price | Quantity | |||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Form | Conjugate | Quantity | Price | Quantity | |||
|
MS107P1ABX
|
Epredia™
MS107P1ABX |
Concentrated | Unconjugated | 100 μL |
N/A
|
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MS107P1
|
Epredia™
MS107P1 |
Concentrated | Unconjugated | 500 μL |
N/A
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MS107R7
|
Epredia™
MS107R7 |
Prediluted | Unconjugated | 7 mL |
N/A
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Description
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.Host Species: Mouse
Clone: 1F8; same as Rb1
Isotype: IgG1
Species Reactivity: Human. Does not react with mouse and rat. Others not known.
Epitope: aa 703-722
Immunogen: Recombinant human Rb protein
Molecular Weight: 105kDa
Positive Control: Ls174T, HT29, HUVEC cells; Normal colon, Breast CA and colon CA
Cellular Localization: Nuclear Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein. It shows no cross reaction with p107 and p130.
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Immunoprecipitation (Native and denatured)
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| Retinoblastoma (Rb) Ab-1 | |
| Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| Mouse | |
| Cancer and Tumor Biology | |
| Recombinant human Rb protein | |
| Primary |
| 1F8; same as Rb1 | |
| Monoclonal | |
| RUO | |
| Human | |
| IgG1 |