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Tocris™ L189

DNA ligase I, III and IV inhibitor

$199.20 - $841.81

Specifications

Product Type L189
Inhibitors L189
Molecular Weight 246.29
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

356110R

 
tocris™
3561/10
10mg Each for $199.20

356150R

 
tocris™
3561/50
50mg Each for $841.81
Description & Specifications

Specifications

Product Type L189
Inhibitors L189
Molecular Weight 246.29

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5μM respectively) that blocks DNA binding (Ki = 5μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

  • Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
  • Formula: C11H10N4OS
  • CAS Number: 64232-83-3
  • Solubility: Soluble to 100mM in DMSO