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Tocris™ L189

DNA ligase I, III and IV inhibitor

$199.90 - $838.64

Specifications

Product Type L189
Inhibitors L189
Molecular Weight 246.29
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Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
356110R Tocris™
356110
10mg Each for $199.90
356150R Tocris™
356150
50mg Each for $838.64
Specifications

Description

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5μM respectively) that blocks DNA binding (Ki = 5μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
  • Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
  • Formula: C11H10N4OS
  • CAS Number: 64232-83-3
  • Solubility: Soluble to 100mM in DMSO
Description & Specifications

Specifications

L189
L189
246.29