L-(+)-Valinol reacts with aldehydes and nitriles to form imines and oxazolines, respectively, for asymmetric synthesis. It is also used for preparation of 4-isopropyloxazolidinones, employed in stereocontrolled aldol and alkylation reactions, synthesis of chiral 2-thiazolidinethiones for aldol reactions, asymmetric alkylation of condensation product with keto acids, asymmetric reactions of its amidines and imines and oxidation of N-protected derivative to the aldehyde.
Soluble in water.
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air. Store under dry inert gas.
|80° to 81°C (8mmHg)|
|30° to 35°C|
|+17° (c=10 in Ethanol)|
Safety and Handling
GHS H Statement
Causes skin irritation.
Causes serious eye irritation.
GHS P Statement
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Take off contaminated clothing and wash before reuse.
Specific treatment (see label).
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Recommended Storage : 2° to 8°C